Candidemia: Retrospective Analysis of Eleven Year Experience

A. SPILIOPOULOU, S. VAMVACOPOULOU, C. BARTZAVALI, L. PICOULA, E. D. ANASTASSIOU, M. CHRISTOFIDOU;

Author address: 

Univ. of Patras, Patras, Greece.

Abstract: 

Background: To investigate the isolation and distribution rate of Candida spp. in blood cultures and to evaluate antifungal susceptibility during an 11-year period (1998-2008) at a tertiary care hospital.Methods: Candida isolates were screened by germ tubes test and identified using API 20CAUX (Biomerieux). Antifungal susceptibility was carried out by E-test (AB Biodisk) and MIC was evaluated according to CLSI criteria for amphotericin B (AM), 5-flucytocin (FC), ketoconazole (KE), itraconazole (IT), fluconazole (FL), voriconazole (VO), posaconazole (PO) and caspofungin (CF). Results: During the study period there were 255 candidemia cases (one or more positive blood cultures for Candida spp isolated from patients with clinical signs of infection). An increasing frequency of Candida isolates varying from 1.33% (8 cases) of all positive blood cultures in 1998 to 4.4% (47 cases) in 2008 was observed. The causative species were: C. albicans 163 strains (64%), C. parapsilosis 35 (13.7%) C. glabrata 25 (9.8%), C. tropicalis 19 (7.4%), other Candida spp 13 (5.1%). Department distribution data are presented at Table 1. Susceptibility data are shown at Table 2. Conclusions: Candidemia is predominantly caused by C. albicans (64%). C. parapsilosis is the most common non-albicans Candida isolated in Neonatal ICU. All Candida isolates remain susceptible to AM, whereas, the highest degree of resistance was observed to IT, FL and KE.
2009

abstract No: 

M-1011

Full conference title: 

49th Annual ICAAC
    • ICAAC 49th