Candida spp. Oral Disease, Colonization and Fluconazole Resistance in HIV/AIDS Patients using Microbiological and Molecular Detection Methods in the Era of Antiretroviral Therapy

W.R. Kirkpatrick, J.E. Erlandsen, L.K. Najvar, A.C. Vallor, G.R. Thompson III, M.L. Herrera, B.L. Wickes, D.K. Berg, S.D. Westbrook, N.P. Wiederhold, S.W. Redding, T.F. Patterson

Author address: 

The University of Texas Health Science Center, SAN ANTONIO, TX, USA


Objectives: The recent prevalence of symptomatic oropharyngeal candidiasis (OPC), colonization, and rate of fluconazole (FLU) resistance due to Candida in HIV/AIDS in patients receiving antiretroviral therapy (ART) has not been well described. This study was designed to detect and identify the occurrence of oral Candida colonization/disease and FLU susceptibility in patients (pts) using standard microbiological and molecular techniques. Methods: HIV/AIDS patients were eligible for enrollment with CD4+ count 8 μg/ml) were detected in 45 (25%) patients. 243 of 311 patient visits (78%) were from patients on ART. Colonization was detected in 260 visits; microbiology was positive in 250 and PCR in 217; 10 were positive exclusively by PCR. Candida species were isolated and identified to the molecular level from 341 total patient visits. Of these isolates, C. albicans was detected in 54%. Other species noted were C. dubliniensis (16%), C. glabrata (17%), C. tropicalis 5%, C. krusei 4%, C. parapsilosis 3% and C. guilliermondii and C. lusitaniae

abstract No: 


Full conference title: 

4th Trends in Medical Mycology
    • TIMM 4th (2012)