Candida Parapsilosis Cerebritis in Acute Lymphobalstic Leukemia Successfully Treated with Caspofungin and High Dose Fluconazole . Session Type: Publication Only

Joanne F. Sutton, Paulette C. Bryant

Author address: 

Pediatric Hematology/Oncology, Naval Medical Center Portsmouth, Portsmouth, VA, USA


Introduction: Systemic fungal infections are a significant cause of morbidty and mortality among immunocompromised patients. Patients with acute lymphoblastic leukemia (ALL) receiving intensive chemotherapy are at high risk for invasive candidiasis. In the past decade, there has been a noted rise in the incidence of non-albican Candida infections. C. parapsilosis has recently been reported to account for 17-19% of the Candida species in the immunocompromised host. Caspofungin is an echinocandin antifungal agent with broad-spectrum activity against Candida. Case Report: A 10-year-old girl with Trisomy 21 and acute lymphoblastic leukemia was admitted for fever and neutropenia on induction day #22. ALL four drug induction of vincristine, L-asparaginase, prednisone, daunomycin, and intrathecal methotrexate was given. The patient had been neutropenic with ANC

abstract No: 


Full conference title: 

American Society of Hematology 45th Annual Meeting
    • ASH 45th (2003)