Between January 1993 and may 1998, we identified 96 immunocompromised cancer patient (Pts) with Candida glabrata fungemia. With the widespread use of Fluconazole prophylaxis after 1992 at our center, the incidence of C.glabrata fungemia increased. Most immunocompromised cancer Pts with C.glabrata fungemia were neutropenic (47%). The underlying disease was leukemia (47%), solid tumor (38%) , and lymphoma(15%) . Most (64%) of these Pts with C.glabrata fungemia received flucnazole prophylaxix prior to the onset of fungemia. Disseminated infection occurred in 37 Pts(39%), while 15% of all c. glabrata fungemia infections were catheter related. Breakthrough candidemia on omphotencin Bor liposomal compound regimen occurred in 10 Pts , 5 of whom had disseminated infection. C. glabrata fungemia was the primary cause of death in 13 Pts (14%) and was a contributing factor to death in 29 other Pts (39%). In conclusion, C.glabrata fungemia in immunocompromised cancer Pts is associated with high frequency of dissemination and mortality. This infection should be considered in any febrile immunocompromised cancer patient.
Full conference title:
13th Annual Focus on Fungal Infections
- FFI 13th (2003)