Burden of aspergillosis-related hospitalizations in Australia

J Fastenau, P Mavros, S Crowley, GM Davies.


Background: Aspergillosis, a severe fungal infection, often results in lengthy hospital stays (LOS) and high mortality rates. We examined trends in admission rates, LOS, and inpatient mortality to evaluate the burden of aspergillosis-related hospitalintions (ARH) in Australia during 1993-99. Method. Data were extracted from the National Hospital Morbidity Database compiled by the Australian Institute of Health and Welfare. An ARH was defined as any acute hospital discharge (AHD) with a diagnosis of aspergillosis or pneumonia in aspergillosis (ICD-9-CM: 117,3,484.6), Logistic regression was used to determine the association between mortality and co-morbid conditions adjusting for sex, age group, insurance type, and public hospital. Result 6,108ARH were identified during 1993-99 representing 0.03% of all AHD. ARH increased by 7 1 % from 1993 m 1999 while all AHD rose by 22%. ARH LOS (12.3 days) and mortality (7.9%) remained unchanged. Compared to allAHD. AIRH LOS was 2.7 times longer and mortality was 5.3 times higher. Based on the reported diagnosis 87% of the ARH were coded with at least one of the following co-morbid conditions: pneumonia (17%), cancer (14%), leukemia (9%), other respiratory infections (68%), and HIV (3%). ARH with pneumonia had the longest LOS (95%CI: 18.2-20.7 days). Higher mortality was associated with ARHs that also had co-morbid conditions for pneumonia (OR 3.1), 95% Cl 23-3.8), cancer (OR 2.2. 95% 17-2.7), leukemia (OR 3.9, 95% Cl 2.9-5.2), and other respiratory (OR 1.3 95% Cl LO- 1.6) when compared to ARHs without these conditions. Conclusion: The number of ARH in Australia has increased. Although ARH account for a small percent of all AHD, patients admitted for an ARH experience high mortality and long LOS.

abstract No: 


Full conference title: 

Trends in Invasive fungal Infections 6, 2001
    • TIFI 6th