Aspergillus carbonarius is related with A. niger for industrial production of citric acid and gluconic acid, which is approved by the World Health Organisation. A. niger can be used for conversion of naringin to naringenin and hesperedin to hesperitin, main bioactive compounds in citrus peels. Naringenin and hesperitin belong to a flavonone that has a bioactive effect on human health as antioxidant, hypolipidemic, vasoprotective, anticarcinogenic, cholesterol lowering activites, anti-inflammatory and carbohydrate metabolism promoter. We expected bioconversion of citrus peels by A. carbonarius also produces naringenin and heperitin. In this study, converted products of citrus peels were analyzed using HPLC. Naringenin and hesperitin were identified in products after 11 days. Then, solvent extraction with fermented citrus peels by A.carbonarius was performed. Several bioactivity assays of the bioconversion products by the time were analyzed on DPPH, tyrosinase, lipase, α-glucosidase and nitric oxide production. As a result, bioconversion of citrus peels showed more antioxidant activity than original and a little inhibition of tyrosinase, lipase and NO production. Also, the products were determined for anti-obesity activity on mouse obesity model. Therefore, bioconversion of citrus peels by A.carbonarius are a useful to produce bioactive compounds, naringenin and hesperitin, from treatment of waste products.
Full conference title:
- ASM 115th (2015)