Azole Resistance in Candida, Aspergillus & Penicillium Species: Results of a Four Year Canadian National Surveillance Study

D. J. HOBAN, B. WESHNOWESKI, T. BELLYOU, E. RIMMER, L. PALATNICK, G. G. ZHANEL

Author address: 

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Abstract: 

Background: Ongoing reports of increasing azole resistance in fungal species have prompted both surveillance of resistance and the evaluation of newer antifungal agents such as second-generation azoles. We undertook a multi-year national surveillance study to assess the prevalence of azole resistance in Candida, Aspergillus and Penicillium species. Methods: 18 tertiary care centres in Canada collected the first 20 blood culture, 10 lower respiratory tract and 10 skin/soft tissue Candida, Aspergillus & Penicillium species deemed clinically significant in 1998, 1999, 2000 and 2001. At the reference site broth microdilution susceptibility testing was performed (NCCLS, 1997) and complete isolate identification. Results: MIC90s (μg/ml) to fluconazole (F), voriconazole (V), ketoconazole (K), itraconazole (I), 5-flucytosine (5FC) and amphotericin B (AB) are shown below. Conclusion: Fluconazole resistance in isolates of Candida albicans, from the Canadian centres tested, remains low (
2002

abstract No: 

M-1528

Full conference title: 

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    • ICAAC 42nd