An Association Between Ground Construction and Invasive Aspergillosis in Renal Transplant Recipients

KATHLEEN BRENNAN, MD1, GREGORY MALAT, Pharm D2, ANNE WILAND, Pharm D2, GRAEME FORREST, MBBS1;

Author address: 

Univ. of Maryland, Baltimore, MD, 2Univ. of Maryland Dept of Pharmacy, Baltimore, MD.

Abstract: 

Background: An institution with nearby construction reported an outbreak of invasive aspergillosis (IA) in 4 renal transplant (RT) recipients in Transplantation, 2003. Our institution had new major construction with groundbreaking in 10/1999 and opening in 11/2002. An evaluation of all IA in RT patients was performed. Methods: We retrospectively reviewed all 24 cases of IA in RT recipients between 1999 and 2003. Data was collected on date and type of RT, rejection episodes, cytomegalovirus (CMV) status, CMV infections, and type of immunosuppression used. Table 1: IA infection by year of renal transplant Year 1999 2000 2001 2002 2003 Totals RT (total) 305 401 369 245 235 1555 IA Cases 4 6 9 4 1 24 Annual Rate (IA/year of RT) 0.98% 2.49%a 1.4% 0.4% 0% Annual Incidence 1.01% 1.5% 2.4% 1.6% 0.4% 1.5% a p0.1, RR 1.3 Thymoglobulin 2 (25%) 4 (25%) NS Sites of Infection Pulmonary (100%) Pulmonary (63%) Abdominal (25%) Sinus (6%) Intravitreal (6%) Aspergillus species A. fumigatus (63%) A. terreus (25%) A. niger (12%) A. fumigatus (100%) Survival 3 (37.5%) 8 (50%) NS * Received RT before 10/1999. "  Received RT between 10/1999 and 11/2002. NS = Not significant. Results: The rate/transplant year of IA infection increased significantly by 2.5 times from 1999 to 2000 (p
2004

abstract No: 

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Full conference title: 

42nd Annual Meeting Infectious Diseases Society of America
    • Infectious Diseases Society of America 42nd