Objective: To study- the in vitro activity of ltraconazole(l), Amphotericin B(AB) and two new antifungal agents, LY303366(LY) and Voriconazole(V) against clinical isolates of Aspergillus spp.Material and Method: We studied 68 Aspergillus spp. (30 A. glaucus(A.glau.), 25 A. fumigatus(A.fumi), 9 A. niger, 2 A. flavus, 2 A. terreus) isolated from clinical specimens and two quality control strains. The susceptibility testing was performed using the broth microdilution method(NCCLS, M38-P document). For AB we used antibiotic n- 3 medium and RPMI 1640 for the other antifungal agents. The endpoints were read visually by prominent growth inhibitions, LY and V) and complete growth inhibition(AB) after 48-72 h. of incubation at 35 - C. Conclusions: I- All strains showed low MICs values to four antifungal agents. 2~The lower CM1s values were for LY303366.
Full conference title:
5th Trends in Invasive and Fungal Infections
- TIFI 5th