Aspergillus exometabolomics: a link to the perfect states?

Jens C. Frisvad, Christian Rank and Thomas O. Larsen

Author address: 

Center for Microbial Biotechnology, Department of Systems Biology, Technical University of Denmark, Building 221, Sí¸ltofts Plads, DK-2800 Kgs. Lyngby, Denmark, e-mail: [email protected]


Aspergillus is a very diverse genus. Twelve perfect states of Aspergillus have been described: Chaetosartorya, Emericella, Eurotium (= Edyuillia), Fennellia, Hemicarpenteles, Hemisartorya, Neocarpenteles, Neopetromyces, Neosartorya, Petromyces, Sclerocleista, & W arcupiella. According to Peterson (2008) five genera: Hemicarpenteles, Sclerocleista and W arcupiella(and other members of the Trichocomaceae) are outside Aspergillus sensu stricto. Species hitherto regarded as having only the imperfect Aspergillus state, have recently been found to have a perfect state (e.g. Neosartorya fumigata and Petromyces parasiticus) and thus sclerotium or ascoma associated secondary metabolites are also potentially additions to the "œfull" profile of potential secondary metabolites anyone species can produce. Furthermore provisional annotation of full genome sequenced Aspergilli have shown that many more secondary metabolites are potential species specific metabolites than have already been discovered. W e have analysed species of Aspergillus and Penicillium and associated teleomorphs for secondary metabolite profiles. Each teleomorph genus is a partially polythetic class regarding secondary metabolites, with few overlaps between teleomorphic genera of Aspergillus. This is in accordance with the large phylogenetic distance between some of these genera: For example Neosartorya (and Aspergillus section Fumigati) species produce a combination of fumigatins, viriditoxins, fumigaclavines, gliotoxins, trypacidins, fumitremorgins, fumiquinazolins, helvolic acids, fumagillins, neosartorin, cyclopiazonic acid while Petromyces (and Aspergillus section Flavi) produce kojic acids, aspergillic acids, cyclopiazonic acids, aflatoxins, asperfuran, oryzaechlorins, aflavinines, aflatrems, so comparing section Fumigati with section Flavi reveals that only cyclopiazonic acid is in common. Examples of the large differences in secondary metabolite combinations between Aspergillus sections will be presented in addition to a discussion on exometabolomics in general.

abstract No: 


Full conference title: 

6th International Aspergillus Meeting
    • Asperfest 6 (2009)