Antifungic activity and effects of extracts of medicinal Brazilian plants on Candida albicans isolated from oral cavity

Resende M.A., Silva D.L., Lyon J.P., Costa C.C., Magalhaes T.F.F., Johann S., Lima H.E., Olivieira M.B., Martins C.V.B.

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Yeasts of the genus Candida does part of the indigenous human microbiota. However, they can behave as opportunistic pathogens, depending of host and fungal factors. The study of virulence factors of the fungus becomes important to an understanding of its pathogenicity and development of antifungal drugs. Plants are known to produce a plethora of secondary metabolites, which are recognized as a useful source of new drugs and leads. A study was conducted in order to evaluate the antifungal activity and effects of ethyl acetate fraction from leaves of Schinus terebinthifolius and Punica granatum, medicinal Brazilian plants, on Candida albicans isolates. The minimum inhibitory concentration for S. terebinthifolius was on average 33.40µg/ml, while for P. granatum was S9.77µg/ml. Both extracts had fungistatic activity upon C. albicans. The treatments with extracts of S. terebinthifolius and P. granatum increased yeasts hydrophobicity, respectively by 14.22% and 33.23%. However, this increase was not significant in relation to control. The extract of S. terebinthifolius inhibited the adherence of yeasts to buccal epithelial cells in 29.59%, and this inhibition was statistically significant in relation to the untreated control (P

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17th International Society for Human and Animal Mycology
    • ISHAM 17th (2009)