ANTIFUNGAL THERAPY OF MURINE INFECTION WITH ASPERGILLUS TERREUS

Najvar LK, Hernandez S, Bocanegra R, Fothergill AW, Graybill JR

Author address: 

University of Texas, San Antonio, United States

Abstract: 

Background: In recent years, Aspergillus terreus has been an increasingly frequent pathogen in both the United States and Europe. Herein, we evaluated posaconazole (POS), amphotericin B (AMB), and caspofungin (CASPO) against A. terreus isolate #R-3371 in a neutropenic mouse model. Methods: The day before infection ICR mice were rendered neutropenic with 5-fluorouracil at 150 mg/kg intravenously (IV) and cyclophosphamide at 200 mg/kg intraperitoneally (IP). Mice were infected IV with 2x105-1.5x107 conidia/mouse. MICs using the NCCLS M38-P method for POS, AMB, and CASPO respectively, at 48 hrs, were 0.06, 2, and
2003

abstract No: 

none

Full conference title: 

13th Annual Focus on Fungal Infections
    • FFI 13th (2003)