Antifungal Susceptibility of Candida Isolates Collected During Population-Based Candidemia Surveillance in Atlanta, Ga and Baltimore, Md, 2008

S. R. LOCKHART1, N. IQBAL 1, K. A. ETIENNE 1, A. M. AHLQUIST 1, M. FARLEY 2, W. BAUGHMAN 3, B. SIEGEL 3, L. H. HARRISON 4, R. HOLLICK 4, S. A. BALAJEE 1, S. S. MAGILL 1, T. CHILLER 1;

Author address: 

1CDC, Atlanta, GA, 2Atlanta VAMC, Atlanta, GA, 3Emory Univ., Atlanta, GA, 4Johns Hopkins Univ., Baltimore, MD.

Abstract: 

Background: Candida is the fourth most common cause of nosocomial bloodstream infections in the U.S. We sought to determine the antifungal susceptibility profiles of Candida isolates collected during an ongoing, population-based candidemia surveillance project. Methods: A total of 571 Candida bloodstream isolates collected in 2008 were submitted to CDC from ongoing population-based surveillance in the 8-county Atlanta, GA metropolitan area and Baltimore City and County, MD. Species determination was performed using a DNA-based Luminex assay. Susceptibility testing was performed using TREK Diagnostic microbroth dilution panels following the recommendations of CLSI M27-A3. Results: In both Atlanta and Baltimore C. albicans was the most prevalent at 39% and 37%, respectively, followed by C. glabrata at 30% and 25%, and C. parapsilosis at 21% and 22%. The incidence of C. albicans has decreased at both sites. The incidence of C. glabrata has increased in Atlanta and the incidence of C. parapsilosis has increased in Baltimore. The five major species complexes accounted for 99% of the total isolates. Drug resistance was as follows: Conclusions: The percentage of C. albicans isolates causing bloodstream infections has decreased from prior studies, while the percentage of C. glabrata and C. parapsilosis has increased. Fluconazole resistance was most common among C. glabrata isolates and SDD rates reached 39%. Echinocandin non-susceptibility, even among C. parapsilosis isolates, was rare.
2009

abstract No: 

M-1927

Full conference title: 

49th Annual ICAAC
    • ICAAC 49th