Antifungal Susceptibilities for Candida Species Isolated from Blood Cultures at a Tertiary Care Hospital in Korea.

J.D. CHAE, M.N. KIM, S.J. YOO, H.Y. PARK

Author address: 

Univ. of Ulsan and Asan Med Ctr, Seoul, Republic of Korea

Abstract: 

Background: Since the first systemic triazoles, fluconazole and itraconazole were introduced in early 90's, an increased resistance to azoles has been reported worldwide. However there was a lack of antifungal susceptibility data because few clinical laboratories test antifungal susceptibility routinely in Korea. This study is purposed to investigate susceptibility of Candida species from blood cultures to amphotericin B and azoles including a newer triazole, voriconazole. Methods: Candida species (132) isolated from blood cultures were collected for two years from 2001 to 2001 (64 C. albicans, 34 C. tropicalis, 20 C. parasilosis, 11 C. glabrata, 2 C. krusei, and 1 other). Minimal inhibitory concentrations (MICs) of amphotericin B, fluconazole, itraconazole and voriconazole were determined by the NCCLS broth microdilution method with reading after 24h incubation. Results: For C. albicans, C. tropicalis, C. parapsilosis, and C. glabrata, MIC90s of amphotericin B and voriconazole were all 1 and 0.5 µg/mL respectively, MIC90 of fluconzaole were 0.25, 0.5, 1, and 4 µg./mL and MIC90 of itraconzaole were 0.03, 0.03, 0.03 and 0.12µg/mL. A C. glabrata strain showed amphotericin MIC of 2 µg./mL and a C. krusei strain was resistant to all agents. While itraconazole MICs were proportionally higher for Candida isolates with high fluconazole MICs (p
2002

abstract No: 

M-1529

Full conference title: 

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    • ICAAC 42nd