Antifungal Prophylaxis is Effective against Murine Invasive Pulmonary Asper~illosis

G. Rieg, B.J. SpeLLberg, J. Schwartz, Y. Fu, J.E. Edwards Jr., D.C. Sheppard, A.S. Ibrahim

Author address: 

Los Angeles Biomedical Research and Institute at Harbor-UCLA, Medical Center Torrance, CA 90502, USA

Abstract: 

Background: Antifunga[ prophylaxis is a promising strategy to prevent and/or ameliorate invasive puLmonary aspergillosis (IPA). Concerns have arisen over the use of prophylactic voriconazoLe, so aLternative antifungaL strategies merit exploration. In particular, Lipid amphotericin formulations are promising prophylactic agents because they accumuLate in tissues, and thus may not require daily administration to mediate protection against the smaLL numbers of inhaled conidia initiating infection. Methods: BALB/c mice with cydophosphamide/ cortisone acetate-induced immunosuppression were infected via inhalation with A. fumigatus. Mice were treated iv prior to infection with AmBisome (LAMB), AbeLcet (ABLC), amphotericin B (AmB), or caspofungin acetate (CAS). Endpoints were survival, colony forming units (CFUs), and histology of lungs. Results: Initially, we compared the efficacy of a single dose of LAmB at 15 mg/kg to a dual treatment close of 7.5mg/kg given every other day. The single 15mg/kg close and the second of the dual 7.5 mg/kg doses were administered 24, 48 or 72 hours prior to infection. Only administration of dual 7.5 mg/kg doses of LAmB at 24 or 48 h prior to infection resulted in equivalent, significant protection as compared to placebo (100% vs 50%, p
2006

abstract No: 

S74

Full conference title: 

14th International Symposium of Infections in the Immunocompromised Host
    • ISIIH, 14th