Antifungal activity of Isavuconazole and comparators against chromoblastomycotic Cladophialophora spp.


Hamid Badali, Sybren de Hoog, Ilse Curfs-Breuker, and Jacques F. Meis
Cladophialophora is a genus of black yeast-like fungi frequently encountered in human Infections. The genus includes species causing chromoblastomycosis and other skin infections, as well as disseminated and cerebral infections, often in immunocompetent individuals. The type species of this genus, Cladophialophoracarrionii, is an agent of chromoblastomycosis, histologi- cally characterized by muriform cells in skin tissue, and another species, Cladophialophora samoensis,recently was described as a new agent of chromoblastomycosis. Few standard thera- pies is available for chromoblastomycosis, andboth extensive surgical excision and prolonged antifungal chemotherapy are required in order to achieve clinical cure. The purpose of this study was to evaluate the in vitroactivity of the experimental antimycotic drug Isavuconazole (ISA) and 7 marketed comparators towards clinical isolates of C.carrioniiand C. samoensis.




abstract No: 

    • TIMM 4th (2012)