Antifungal Activity of Caspofungin and the New Triazoles Compared with Itraconazole and Amphotericin B against 462 Recent Clinical Isolates of Aspergillus and Other Filamentous Fungi

D. J. Diekema, S. A. Messer, R. J. Hollis, R. N. Jones, M. A. Pfaller

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Background: Effective treatment options for invasive filamentous fungal infections are needed. Echinocandins and the new triazoles may hold promise for these difficult infections. We compared the in vitro activity of caspofungin (CASP), posaconazole (POSA), voriconazole (VORI), ravuconazole (RAVU) itraconazole (ITRA) and amphotericin B (AMB) against a large collection of clinical mould isolates. Methods: 462 clinical isolates of filamentous fungi (including 257 A. fumigatus, 30 A. flavus, 29 A. niger, 21 A. versicolor, 16 A. terreus, 37 Penicillium spp., and 11 Fusarium spp.) were collected during 2000-2001 from 15 centers in the US and Canada. Minimum inhibitory concentrations (MICs) were determined according to the NCCLS M38-P method. The endpoint for reading CASP was the minimum effective concentration (MEC). The % inhibited at

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    • ICAAC 42nd