Alternaria species are the 2nd cause of invasive fungal infections among oncohematological patients at one institution: possible role of high environmental exposure.

Dignani M 1, Tula L 1, Abrantes R 2, Davel G 2, Brudny M 2, Refojo N 2, Garcia-Damiano M 1, Farias E 1, Perrotta D 2

Author address: 

1 FUNDALEU, Buenos Aires, Argentina, 2 Dept Micologia. Administracion Nacional De Laboratorios E Institutos De Salud, Buenos Aires, Argentina


Introduction: During the last decades, the prevalence of candidiasis has been decreasing and molds have become the major cause of IFI among immunocompromissed patients. While Aspergillus spp. are the most prevalent opportunistic molds, Fusarium spp, Zygomycetes, and Scedosporium spp, are also frequently reported. In our institution, Alternaria spp. are the second fungal pathogen following Aspergillus spp. Since Alternaria spp. have not been reported with such a high prevalence, we decided to conduct an investigation. Objective: To analyze the clinical characteristics of patients with invasive alternariosis and to evaluate the prevalence of Alternaria spp. in the hospital air. Material and methods: From 3/97 to 2/03, the charts of patients with probable or documented alternariosis were reviewed. Demographic and clinical data was obtained from each case. In the spring of 2004, the hospital air was studied for detection of fungi by using two methods: sedimentation plate (SP) and a portable volumetric method (SAS super 90® , pbi, Milan, Italy). (PVM). Sampling was done simultaneously with the 2 methods in 44 indoor and 5 outdoor sites, 3 /day. Results: Patients: Nine patients with alternariosis were found. The mean age was 48 , and 6/9 were males. The underlying diseases were non Hodgkin lymphoma (3), acute (2) and chronic myeloid leukemia (2), acute lymphoblastic leucemia (1) and multiple myeloma (1). Five patients had relapsed disease, 8 patients were neutropenic (ANC

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Full conference title: 

15th Annual Focus on Fungal Infections
    • FFI 15th (2005)