African histoplasmosis in and outside Africa

Dupont, B.

Author address: 

Université Paris Descartes, Hopital Necker, Paris, France


The dimorphic fungus Histoplasma capsulatum (Hc) has two varieties: Hc var. capsulatum and Hc var. duboisii (Hd), the agent of African histoplasmosis (AH). Area of endemicity to Hd is restricted to subsahelian Central/West Africa and Madagascar. Cases seen in Europe are imported or result from a laboratory traumatic cutaneous inoculation (1 case) The epidemiology of Hd infection in poorly understood: the natural habitat of the mycelial form of Hd is unknown, the mode of contamination is uncertain: inhalation, skin or gastrointestinal tract as portal of entry? In a retrospective review of 23 imported cases into France, in HIV negative patients, between 1968-1996, patients were caucasian n=12 or Black African n=11; mean age was 35.5y (12-62), sex ratio M/F was 9.5. Mean duration of residency in Africa was 12y (2-24) indicating that AH is not a disease contracted during a short trip. AH may remain dormant and can be reactivated more than 10 years after return. Clinically fever was absent in 10 pts,

abstract No: 


Full conference title: 

3rd Trends in Medical Mycology
    • TIMM 3rd (2011)