aflatrem

Toxin: 

y

Systematic name: 

4H-3,15a-Epoxy-1-benzoxepino[6',7':6,7]indeno[1,2-b]indol-4-one, 9-(1,1-dimethyl-2-propenyl)-2,3,5b,6,7,7a,8,13,13b,13c,14,15-dodecahydro-5b-hydroxy-2,2,13b,13c-tetramethyl-, (3R,5bS,7aS,13bS,13cR,15aS)-

Molecular formulae: 

C32H39NO4

Molecular weight: 

501.67

Chem abstract number: 

70553-75-2

Literature reference: 

Indole metabolites from a strain of Aspergillus flavus. Cole, Richard J.; Dorner, Joe W.; Springer, James P.; Cox, Richard H. (Natl. Peanut Res. Lab., Sci. Educ. Adm., Dawson, GA 31742, USA). J. Agric. Food Chem., 29(2), 293-5 (English) 1981. Multiple toxin production by an isolate of Aspergillus flavus. Richard, J. L.; Gallagher, R. T. From Mycopathologia (1979), 67(3), 161-3. Aflatrem, the tremorgenic mycotoxin from Aspergillus flavus. Gallagher, Rex T.; Wilson, Benjamin J. From Mycopathologia (1979), 66(3), 183-5

Chemical type: 

Alkaloid

Toxicity: 

The first tremorgenic mycotoxin to be isolated. An oral dose of 1 mg given to mice causes tremors, especially in response to attempts to move. The symptoms increase in severity after 1-2 h. but recovery usually occurs after 24-48 h.

Structure image: 

Aspergillus Species known to produce this metabolite: 

3d image file .s3d (get free desktop viewer at http://www.acdlabs.com/resources/freeware/): 

Date uploaded: 

0000-00-00 00:00:00