Cyclopenta[c]furo[3',2':4,5]furo[2,3-h]benzopyran-1,11-dione, 2,3,6a,9a-tetrahydro-4-methoxy-, (6aR-cis)-
Chem abstract number:
Production of aflatoxin by the culture of strains of Aspergillus flavus-oryzae on sterilized peanuts. Codner, R. C.; Sargeant, K.; Yeo, R. Microbiol. Res. Estab., Porton, UK. Biotechnology and Bioengineering (1963), 5 185-92. Toxicity and fluorescence properties of the aflatoxins. Carnaghan, R. B. A.; Hartley, R. D.; O'Kelly, J. Nature (London, United Kingdom) (1963), 200(4911), 1101. Toxic metabolites of Aspergillus flavus. Hartley, R. D.; Nesbitt, Brenda F.; O'Kelly, J. Nature (London, United Kingdom) (1963), 198, 1056-8
Primarily an hepatotoxin and in some species, such as the rat and the rainbow trout, an hepatocarcinogen and mutagen. Toxic response depends on how the molecule is metabolised in the liver. Oral LD50 for adult male rat 7.2 mg/kg, adult dog 0.5 mg/kg and day-old duckling 0.35 mg/kg body-weight, respectively. Possibly associated with human liver cancer in association with hepatitis B infection.
Aspergillus Species known to produce this metabolite: