Acute fungal sinusitis in neutropenic patients

Parisa Badiee, Parivash Kordbacheh, Abdolvahab Alborzi, Bita Geramizadeh & Mani Ramzi

Author address: 

1Dept of Medical Parasitology and Mycology, School of Public Health and Institute of Public Health Research; 2Prof. Alborzi Clinical Microbiology Research Center; 3Dept of Solid Organ Transplant Research Center; 4Dept of Hematology and Bone Marrow


Introduction Fungal sinusitis is a well-documented disease in immunocompromised patients, but recently many reports have indicated an increased prevalence of fungal sinusitis in otherwise healthy individuals. The aim of this study was to review our experience with neutropenic patients with invasive fungal sinusitis (IFS) to determine outcomes and identity factors that may affect patient’s survival. Methods 142 patients who were undergoing chemotherapy were followed by clinical and radiological finding suggestive of fungal sinusitis. Two diagnostic criteria for invasive fungal sinusitis are proposed: sinusitis confirmed by radiological imaging and histopathological evidence of hyphal forms within sinus mucosa, sub mucosa, blood vessels or bone. Patients with fever, headache, facial swelling and radiological finding underwent endoscopic sinus surgery. The biopsy material studied by mycological and histopathological methods. Results Eleven from 142 patients were identified IFS. Eight of 11 cases dieds.( 72.8%) The ethiologic agents were Aspergillus flavus (5cases), Alternaria sp. (3cases), Aspergillus fumigatus (2cases) and mucor (1 case). Conclusions The clinical challenge of diagnosing and treating IFS is evident by the high mortality rates for this diagnosis. Early diagnosis with aggressive medical and surgical intervention is critical for survival.

abstract No: 

CM 18

Full conference title: 

161st Society for General Microbiology
    • SGM 161st (2007)