Activity of faropenem for 146 fluoroquinolone-resistant bacteria

L. J. V. Piddock, M. A. Webber


Objectives: To determine the activity of faropenem (FAR) for 146 fluoroquinolone-resistant bacteria (MIC of ciprofloxacin > = 2 µg/mL) with known mechanisms of fluoroquinolone resistance, and compare the data for FAR with that of ciprofloxacin (CIP) and imipenem (IMI). Methods: The MIC of each agent was determined by the agar doubling dilution method. The MIC of IMI was determined for all strains with an MIC of FAR > = 0.5 µg/mL. Results: FAR was very active against E. coli with an MIC50 of 0.125 µg/mL, and an MIC90 of 0.25 µg/mL. FAR was also very active against S. pneumoniae with an MIC50 of = 1 µg/mL for inhibition). Enterococci, collected from a variety of sources, were resistant to FAR with an MIC50 of 16 µg/mL and an MIC90 of > 32 µg/mL. Likewise, FAR was less active against B. fragilis with an MIC50 of 0.5 µg/mLand an MIC90of8 µg/mL (3/26 strains required > = 1 µg/mL for inhibition). Notably, all bacterial strains with an MIC of > 0.5 µg/mL of FAR were also less susceptible to IMI.

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11th European Congress of Clinical Microbiology and Infectious Diseases
    • ECCMID 11th (2001)