Rhodotorula species are common airborne organisms which may be present on the skin, in sputum, urine or faeces. It is usually considered to be nonpathogenic, but it has been documented to cause severe infections mainly by immunocompromised patients (solid tumour, lymphoproliferative disease, organ transplantation, chronic renal failure, diabetes mellitus and AIDS). We report the case of a peri-renal abscess caused by Rhodotorula sp. in a kidney transplant recipient. Considering the cases reported in the literature, this commensal yeast has been involved in fongaemia, peritonitis, meningitis, endocarditis, conjonctiva infection, etc…). Apart from immunosuppression, the presence of an intravenious catheter or a peritoneal catheter is considered as being a major predisposing factor for Rhodotorula infection. Considering the therapeutic approach, removal of the catheter alone led sometimes to the remission of Rhodotorula infection; however, an antifungal therapy is often started. Despite the limited data concerning Rhodotorula susceptibility, several antifungal therapies have been used. We evaluated the in vitro activities of 8 antifungal agents on 30 strains of Rhodotorula (21 strains of R. rubra and 9 strains of R. glutinis). All strains tested were susceptible to amphotericin B, 5FC, and nystatin but resistant to fluconazole and itraconazole. MIC to fluconazole was •256 mg / l ; MIC to itraconazole was •3 mg / l for Rhodotorula rubra and •32 mg / l for Rhodotorula glutinis.
Full conference title:
The 15 th Congress of the International Society for Human and Animal Mycology
- ISHAM 15th (2003)