α-sarcin

Toxin: 

n

Systematic name: 

2-Amino-1-methyl-9H-purine-6-thione
 9H-Purine-6-thione, 2-amino-1-methyl-
 Purine-6(1H)-thione, 2-amino-1-methyl-
 6H-Purine-6-thione, 2-amino-1,7-dihydro-1-methyl- (9CI)

Molecular formulae: 

C6H7N5S

Molecular weight: 

181.219

Chem abstract number: 

1320-87-2

Literature reference: 

Lin A, Huang KC, Hwu L, Tzean SS. Toxicon. 1995 Jan;33(1):105-10. Production of type II ribotoxins by Aspergillus species and related fungi in Taiwan. OLSON BH, GOERNER GL. ALPHA SARCIN, A NEW ANTITUMOR AGENT. I. ISOLATION, PURIFICATION, CHEMICAL COMPOSITION, AND THE IDENTITY OF A NEW AMINO ACID. Appl Microbiol. 1965 May;13:314-21. Kao R, Davies J. Fungal ribotoxins: a family of naturally engineered targeted toxins? Biochem Cell Biol. 1995 Nov-Dec;73(11-12):1151-9. Review.

Toxicity: 

mouse LDLo 50mg/kg (50mg/kg) Journal of Medicinal and Pharmaceutical Chemistry. Vol. 5, Pg. 996, 1962.

Structure image: 

Aspergillus Species known to produce this metabolite: 

3d image file .c3d (requires Chem3d http://www.cambridgesoft.com/Ensemble_for_Chemistry/ChemBio3D/): 

jmol file (.mol) requires Java to run (http://www.java.com/en/download/help/enable_panel.xml): 


Date uploaded: 

2008-07-07 13:14:58