Why are Aspergilli so different in their expression of secondary metabolites from section to section?

Ref ID: 18376

Author:

Jens Christian Frisvad* and Thomas
Ostenfeld Larsen.

Author address:

Department of Systems Biology, Technical University of Denmark, Kgs, Lyngby, Denmark, * JCF@bio.dtu.dk

Full conference title:

Asperfest 8

Abstract:

Aspergillus species can produce an very large number of secondary metabolites and have a lot of these in common with Penicillium spp. related to the
perfect state Eupenicillium. Some of these extrolites have exclusively been found within Aspergillus and Penicillium, including ochratoxins, aspergamides,
mycophenolic acids, fumagillins, roquefortines, paxillins etc., while Aspergilli and Penicillia share secondary metabolites with widely different genera
in other cases. The latter extrolites include citreoviridin, citrinin, melleins, patulin, pseurotins, penicillic acids, sterigmatocystins, xanthomegnins, simple
diketopiperazines, gliotoxins, etc. Interestingly within Aspergillus sections there are major differences and few secondary metabolites in common.
Aspergillus section Candidi species are known for production of terphenyllins, candidusins, xanthoascins, and chloroflavonins not found in any other
section of Aspergillus. In section Circumdati ochratoxins, aspergamides, penicillic acids, ochratoxins, xanthomegnins, melleins, circumdatins are common.
The aspergamides in section Circumdati are the optical antipods of aspergamides in section Versicolores, so even within Aspergillus sections, there are
very interesting differences. We will suggest some explanations for these major differences between species sections.

Abstract Number: 53)

Conference Year: 2011

Link to conference website: NULL

New link: NULL

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