What is the significance of aspergillus fumigatus in BAL in children with cystic fibrosis

Ref ID: 18426

Author:

Rebecca Thursfield, Andrew Bush, Alex Adams, Andrew G. Nicholson,
Katy Holden

Author address:

Department of Paediatric Respiratory Medicine, Royal Brompton
Hospital, London, United Kingdom; Department of Histopathology, Royal
Brompton Hospital, London, United Kingdom

Full conference title:

European Respiratory Congress

Abstract:

Background: Aspergilllus fumigatus (AF) is frequently found in the airways
of children with cystic fibrosis (CF) and recent evidence suggests this may be
clinically important. (Chest 2006;130:222, Ped Pulm 2007;42:785)
Aims: In this retrospective study, we hypothesised that children with CF who
have AF seen on direct staining of bronchoalveolar lavage (BAL) will have a
worse clinical state than both those who only culture AF (positive controls) and
those with no isolation (negative controls). Primary outcome was FEV1; secondary
outcomes included BMI, IgE, IV antibiotics, steroids and antifungals.
Results: In the year prior to bronchoscopy (FOB), the groups were similar in
terms of weight centile, IV antibiotics received and FEV1. One year post FOB,the groups with AF in their BAL, on cytology or microscopy, had a lower FEV1
despite receiving more IV antibiotics and more antifungal therapy. The group without AF had a greater increase in FEV1. Conclusion: The results add to the growing evidence that AF in the airways of
children with CF is associated with a worse clinical state, whether identified on
direct smear or culture.

Abstract Number: 4660

Conference Year: 2011

Link to conference website: http://www.ers-education.org/ersMade/abstract_print_11/files/Abstract_book_2011.pdf

New link: NULL

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