Using Pharmacodynamics to Set Antifungal Susceptibility Breakpoints

Ref ID: 18732

Author:

Russell Lewis, PharmD – Senior Researcher

Author address:

Univ. of Bologna, Bologna, Italy.

Full conference title:

52nd Annual ICAAC

Date: 9 September 2014

Abstract:

The development of clinical susceptibility breakpoints for antifungals is complicated by the wide inter-patient pharmacokinetic variability of some agents, as well as multiple host-related factors that influence treatment response for opportunistic fungal infections. Consequently, the relationship between antifungal MICs and clinical response is often obscured, even in datasets derived from prospective, randomized trials. Hence, the major goal of pharmacodynamic (PD) analyses in the breakpoint process is to clarify the relationship between patient drug exposure indexed to the MIC, and the probability of treatment response. PD analysis also revealed the need for Candida species-specific breakpoints, and revision of susceptibility breakpoints for triazole and echinocandin antifungals.

Abstract Number: 414

Conference Year: 2012

Link to conference website: NULL

New link: NULL

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