Transcriptional links between light and development in Neurospora crassa

Ref ID: 18496

Author:

Carmen Ruger-Herreros, Luis M. Corrochano 

Author address:

University of Sevilla

Full conference title:

11 th European Conference on Fungal Genetics

Abstract:

The ascomycete fungus Neurospora crassa grows as a branched mycelium with interconnected hyphae during the
vegetative phase of its life cycle. Several environmental cues, including blue light, promote a developmental
transition that leads to the development of conidiophores and the production of conidia. Several mutants have
been isolated that are blocked at different stages of conidiation. One of them, fluffy, has been investigated in some
detail. The FLUFFY (FL) protein is a 7928208;aminoacid polypeptide containing a Zn2Cys6 binuclear zinc cluster domain
belonging to the Gal4p family. Blue light activates fl, and light regulation requires the products of genes wc8208;1 and
wc8208;2 that bind transiently to the promoter of fl. The activation by light of key regulatory genes may explain the
activation by light of conidiation in Neurospora. In Aspergillus nidulans, another ascomycete, several genes
responsible for the formation of conidiophores are activated by light and their Neurospora homologs have been
identified in the Neurospora genome. We have investigated the regulation by light of these putative regulatory
genes in the Neurospora crassa wild type and 8710;fl strains and we have found that deletion of fl promotes a light8208;
dependent accumulation of mRNA of some of these putative developmental genes. Our results suggest an
interaction between FL and the White8208;Collar complex in the promoter of light and developmentally regulated
genes.

Abstract Number: PR7.6

Conference Year: 2012

Link to conference website: http://www.ecfg.info/images/Abstract_Book_Electronic.pdf

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