Introduction: Specific IgE testing is a valuable tool for assessing allergy where skin prick testing is not practical,
Objectives: To determine the level of serum total IgE which is predictive of a positive specific IgE, and whether this varies by
Methods: Data was collected on all IgE measurements collected during 2011 in our institution. Those that had at least one specific IgE measured were selected (n=1518). ROC curves were used to detect the level of total IgE at which 90% and 95% sensitivity for any positive specific IgE was obtained. The data was analysed by
Results: Total serum IgE was predictive of a positive specific IgE with an AUC of 0.759. A sensitivity of 95% was obtained at 21.5IU/mL with a specificity of 32.6%, whereas 90% sensitivity was achieved at 33.5IU/mL giving 43.4% specificity.
The most frequently requested specific IgEs were Aspergillus (n=802), House Dust Mite (n=466), grass pollen mix (n=373), cat dander (n=329), dog dander (n=179), tree pollen mix (n=142), peanut (n=126) and milk (n=108). ROC curve analysis for Aspergillus and House Dust Mite specific IgEs showed 95% sensitivity for
Conclusions: The total IgE threshold for detection of positive specific IgEs varies by
Full conference title:
- ERS 26th (2016)