The TLR2/MyD88, an inhibitory pathway of the allergic response induced by Aspergillus fumigatus spores through the IL-10 cytokine


Pauline Percier-Lehebel

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European Academy of Allergy and Clinical Immunology Congress 2019

Date: 20 August 2020


Aspergillus fumigatus is one of the most ubiquitous of the airborne saprophytic fungi. This fungi species can induce serious diseases like aspergillosis, allergic Aspergillus sinusitis. However, this aggressive fungi species can also activate detrimental Th2 responses in the lungs leading to the development of an allergic inflammation in such hosts. The early events inducing the allergic inflammation induced by Aspergillus fumigatus are actually not defined.

Bone marrow-derived dendritic cells (BMDCs) from wild type or deficient C57Bl/6 mice were stimulated in vitro with Aspergillus fumigatus conidia and then transferred into wild type mice by intranasal administration. Fourteen days after the transfer, all mice were challenged with conidia intra-nasally and the lung inflammations were analysed three days later.

This fungus species induced a strong lung Th2 response with a high recruitment of eosinophils in broncho-alveolar lavages and an increase of Th2 cytokine mRNA in lung homogenat.
The transfer of BMDCs deficient for the expression of MyD88 induced a worsening of the allergic lung inflammation, which is specific of the Aspergillus fumigatus species. Same results were observed with the transfer of TLR2 deficient BMDCs and addition of a TLR2 ligand (PamCSK4) in the culture of WT BMDCs pulsed with Aspergillus fumigatus reduced significantly the allergic lung inflammation.
However, when BMDCs were unable to produce IL-10, this induced an increase of the allergic inflammation.

These results indicate that the TLR2/MyD88 pathway on BMDCs is able to control the allergic response generated by Aspergillus fumigatus probably through the production of IL-10 cytokine.

Abstract Number: LBOA1708

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EAACI 2019

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