The forkhead gene fkhA positively regulates sexual development in Aspergillus nidulans

Ref ID: 18475

Author:

Dong-Soon Oh, Jong-Hwa Kim, Dong-Min Han, Kap-Hoon Han

Author address:

Woosuk University,
Wonkwang University

Full conference title:

11 th European Conference on Fungal Genetics

Abstract:

In a homothallic filamentous fungus Aspergillus nidulans, sexual developmental process is largely affected by the
genetic and environmental factors. To regulate the corresponding genes necessary for the sexual development,
tight regulations of transcription factors are required. Here, we identified the fkhA gene which encodes a putative
forkhead transcription factor homologous to the yeast FKH1 gene that is involved in sexual development. The fkhA
deletion resulted in the complete loss of fruiting body formation under all conditions favoring sexual development,
indicating that the fkhA gene is required for normal sexual development in A. nidulans. Furthermore,
overexpression of fkhA showed enhanced production of fruiting bodies under induction condition not only in the
normal condition but also in the inhibiting condition of sexual development. These results suggest that the fkhA
gene is necessary and sufficient for regulating sexual development in A. nidulans. [This work was supported by the
NRF grant 20118208;0027448]

Abstract Number: PR2.7

Conference Year: 2012

Link to conference website: http://www.ecfg.info/images/Abstract_Book_Electronic.pdf

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