The chemical heritage of A. flavus in A. oryzae RIB40

Ref ID: 18377

Author:

Christian Rank*, Marie Louise Klejnstrup, Lene Maj Petersen, Jens Christian Frisvad,
Thomas Ostenfeld Larsen.

Author address:

Department of Systems Biology, Technical University of Denmark * cr@bio.dtu.dk

Full conference title:

Asperfest 8

Abstract:

Aspergillus oryzae is a very important species in biotechnology and has been used for centuries in traditional Asian fermentation. The RIB40 strain is
particularly interesting as it was one of the first genome sequenced aspergilli together with A. flavus, a prominent food and feed contaminant capable of
producing aflatoxin. These species can be perceived as ecotypes. We have analyzed A. oryzae RIB40 and found that the chemical potential could be
enhanced significantly under certain conditions. Delicate analysis of their metabolic profiles allow for chemical insight on the transcription level with
indications to specific genetic changes. Several new metabolites and changes in biosynthetic routes have been found in A. oryzae, indicating subtle changes
in the genomic heritage from A. flavus.

Abstract Number: 54)

Conference Year: 2011

Link to conference website: NULL

New link: NULL

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