The Antifungal Pharmacodynamic Target: Impact of Organism, Host, and Infection

SCY-247, a novel second-generation IV/oral triterpenoid antifungal, is efficacious in the neutropenic mouse model of pulmonary mucormycosis

v

Teclegiorgis Gebremariam [MS]¹, Yiyou Gu [PhD]¹, Sondus Alkhazraji [PhD]¹, Jousha Quran¹, Laura K. Najvar [BS]², Nathan P. Wiederhold [PharmD]², Thomas F. Patterson [MD]², Scott G. Filler [MD]^1,3, David A. Angulo (MD)⁴, Ashraf S. Ibrahim [PhD]^1,3*,

2024

91

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Evaluation of in vitro Activity, Cytotoxicity, and in vivo Efficacy of Novel Liposomal Formulations of Amphotericin B in Comparison to Natamycin and Liposomal Amphotericin B (AmBisome) in a Murine Model of Experimental Mycotic Keratitis caused by Aspergillus fumigatus

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Ruta Petraitiene (US)

2024

90

n/a

Fighting Aspergillus infection using biocontrol bacteria: A proof of concept study for environmental interference in a translational setting

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Fabio Palmieri (CH), Junier Pilar

2024

89

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Revitalizing our antifungal arsenal with natural products isolated from Arctic bacteria

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Evelyne Côté (CA)

2024

88

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In vivo antifungal screening against triazole-resistant and -susceptible Aspergillus fumigatus using bioluminescence imaging in Galleria mellonella

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Eliane Vanhoffelen (BE)

2024

87

n/a

Efficacy assessment of SF001, A 3rd generation polyene antifungal, in the neutropenic mouse model of invasive pulmonary aspergillosis and mucormycosis

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Teclegiorgis Gebremariam, Yiyou Gu, Eman Youssef, Sondus Alkhazraji, Joshua Quran, Nathan P. Wiederhold, Ashraf S. Ibrahim

2024

86

n/a

Polymeric nanoparticles for the delivery of antifungal drugs into pathogenic fungi

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Thomas Orasch (DE)

2024

85

n/a

Can polymeric particles potentially deliver antifungals inside phago(lyso)somes containing intracellular persistent conidia of Aspergillus fumigatus?

v

Julien Alex, Katherine González, Gauri Gangapurwala, Antje Vollrath, Zoltán Cseresnyés, Christine Weber, Justyna A. Czaplewska, Stephanie Hoeppener, Carl-Magnus Svensson, Thomas Orasch, Thorsten Heinekamp, Carlos Guerrero-Sánchez, Marc Thilo Figge, Ulrich S. Schubert, Axel A. Brakhage

2024

84

n/a

Lateral thinking is key to all the secrets in the world

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Vasireddy Teja, Bibhuti Saha Hod, Soumendranath Haldar (IN)

2024

83

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Troubled waters and puzzled doctors

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Vasireddy Teja, Bibhuti Saha Hod, Soumendranath Haldar (IN)

2024

82

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