The additional D-galacturonate reductase genes in Aspergillus niger and Hypocrea jecorina

Ref ID: 18374

Author:

Joosu Kuivanen, Satu Hilditch, Dominik Mojzita,
Merja Penttilä and Peter Richard

Author address:

VTT Technical Research Centre of Finland, Espoo, Finland joosu.kuivanen@vtt.fi

Full conference title:

Asperfest 8

Abstract:

Pectin, a cheap and abundant raw material has a huge potential in white biotechnology. D-galacturonate, the main component of pectin, is catabolised
to pyruvate and glycerol through a reductive pathway in eukaryotic microorganisms like filamentous fungi. This pathway also enables the utilization of
pectin for the production of more valuable compounds. An example from that is the production of meso-galactarate (mucic acid) in metabolically
engineered fungal strains. Enzymes functioning on the reductive D-galacturonate pathway are a D-galacturonate reductase, L-galactonate dehydratase,
2-keto-3-deoxy-galactonate aldolase and glyceraldehyde reductase. The genes coding for these enzymes in Aspergillus niger are gaaA, gaaB, gaaC and
gaaD, respectively, while in Hypocrea jecorina (Trichoderma reesei) the corresponding genes are gar1, lgd1, lga1 and gld1. A. niger also has a
homologue gene sequence for H. jecorina gar1 whereas H. jecorina has a homologue gene sequence for A. niger gaaA respectively. Functions of these
two additional D-galacturonate reductase genes have remained unclear. We have now studied the roles of these two genes.

Abstract Number: 52)

Conference Year: 2011

Link to conference website: NULL

New link: NULL

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