Systems Biology of Industrially Important Filamentous Fungi

Ref ID: 18440

Author:

Nielsen J

Author address:

Department of Chemical and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden

Full conference title:

11 th European Conference on Fungal Genetics

Abstract:

Aspergilli are used extensively in the fermentation industry for the production of a range of different industrial
enzymes, organic acids and high8208;value secondary metabolites. In connection with further development of
bioprocesses for the production of fuels and chemicals these fungi are interesting versatile cell factories as they
tolerates low pH, can utilize a wide range of carbon sources and has relatively high conversion rates. Furthermore,
their metabolism extends to cover many different secondary metabolites. Due to these factors the metabolism of
Aspergilli is quite complex and involves a very large number of enzyme catalyzed reactions, probably among the
microorganisms containing the largest number of metabolic capabilities. With the availability of the genome
sequence for several different Aspergilli it has become possible to query the metabolic capabilities of these
microorganisms at the genome8208;level. Using a bottom8208;up approach using genomic information together with
information from databases, research papers and books, we have reconstructed the metabolic networks of A.
nidulans, A. niger, A. oryzae and P. chrysogenum. We have used these metabolic networks for gaining novel insight
into the metabolic functions of these organism through integrative analysis of different kinds of data, e.g. data
from genome8208;wide transcription analysis. Among the processes studied are carbohydrate metabolism (use of
different carbon sources like glucose, xylose and glycerol), enzyme production and penicillin production.

Abstract Number: PL4.3

Conference Year: 2012

Link to conference website: http://www.ecfg.info/images/Abstract_Book_Electronic.pdf

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