Susceptibility of clinical isolates of Aspergillus spp . from Russia to amphotericine B and itraconazole

Ref ID: 19579

Author:

NV Vasilyeva1,2*, IA Riabinin1,2, TS Bogomolova1,2, GA Chilina1, ON Pinegina1,2

Author address:

1Kashkin Research Institute of Medical Mycology, Mechnikov North-Western State Medical University,
Saint-Petersburg, Russia
2Chair of Medical Microbiology, Mechnikov North-Western State Medical University, Saint-Petersburg,
Russia

Full conference title:

6th Advances Against Aspergillosis 2014

Abstract:

Purpose:
The purpose of this work is to study the distribution of different minimal inhibitory concentrations
(MICs) to amphotericin B (AmB) and itraconazole (ITZ) among clinical strains of Aspergillus spp.,
which were isolated in Saint-Petersburg, Russia.
Methods:
In this study were used clinical strains of Aspergillus spp. from Russian collection of pathogenic
fungi (numbers of strains tested to ITZ / AmB are in brackets): A. fumigatus (20/11), A. flavus (12/10),
A. oryzae (1/1), A. niger (18/13), A. terreus (3/3), A. glaucus (2/2), A. nidulans (1/1), A. clavatus
(1/0), A. sydowii (1/1), A. candidus (1/1) and A. calidoustus (1/0). Strains were previously isolated
mainly from respiratory substrates (BAL and sputum), but also from external ear, corneal scraping,
autopsy materials, cerebrospinal fluid and some other sites. Susteptibility testing was performing
according protocol EUCAST E.DEF 9.1.
Results:
The results are performed in Table 1. There are MICs for rare clinical isolates obtained in our study
(ranges or values in μg/ml for ITZ/AmB are in brackets; NT – not tested): A. oryzae (0,125/4),
A. glaucus (0,25 – >16/0,0625), A. clavatus (4/NT), A. candidus (<0,0313/4), A. calidoustus (>16/NT).
Conclusion:
As can be seen from the table, obtained MICs ranges are in generally close to ranges performed
by EUCAST, except ranges for A. flavus to ITZ as well as to AmB because of resistant strains
with more high values of MICs. Proportions of resistant strains of A. fumigatus to AmB, strains
of A. niger to AmB and strains of A. flavus to ITZ are higher with comparison to EUCAST data.
However, to determine the statistical significance of these features the study on extended selection
of isolates is needed.

Abstract Number: 104

Conference Year: 2014

Link to conference website: http://www.AAA2014.org

New link: NULL

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