Study the antifungal activity of new imidazole , benzimida – zoles , triazoles , benzotriazoles and tetrazoles derivatives against Aspergillus flavus and Aspergillus fumigatus

Ref ID: 19553

Author:

K Zomorodian1*, Z Rezaei2, S Khabnadideh3, BBF Mirjalilia4, L Zamani4, K Pakshir5, G Kashi2,
N Sanagoei2, S Gholami2, S Zomorodian1

Author address:

1Medical Mycology and Parasitology, Shiraz University of Medical Sciences, Shiraz, Iran
2Medicinal Chemistry, Shiraz University of Medical Sciences, Shiraz, Iran
3Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shira

Full conference title:

6th Advances Against Aspergillosis 2014

Abstract:

Purpose:
Aspergillus species are associated with diseases ranging from simple onychomycosis to lifethreatening
infections in immunocompromised patients. During the past two decades, resistance
to established antifungal drugs has increased dramatically and has made it crucial to identify novel
antimicrobial compounds. In this study, the antifungal activity of novel imidazole, benzimidazoles,
triazoles, benzotriazoles and tetrazoles derivatives against Aspergillus spp were examined and the
possible association of their structure and effects were determined.
Methods:
Five new derivatives of triazoles, three of benzotriazoles, five of imidazoles and three of benzoimidazoles
were designed as inhibitors of cytochrome P450 14a-demethylase. Moreover, nine
derivatives of benzimidazoles and 13 of tetrazoles were also been synthesized in the presence of
nano-TiCl4.SiO2 as a reusable and efficient catalyst. The chemical structures of the new compounds
were confirmed by elemental and spectral (1H-NMR and Mass) analyses. The antimicrobial activities
of the synthetic compounds have been tested against the A. flavus (ATCC 64025) and A. fumigatus
(ATCC 14110) by broth microdilution method as recommended by CLSI.
Results:
Inhibition studies showed that some of the tested compounds, in particular 1-(diphenylmethyl)-
1H-imidazole and 1-[(4-chlorophenyl)(phenyl)methyl]-1H-imidazole, exhibited strong antifungal
activities against the tested fungi followed in activity by 2-(2,3-dihydroxyphenyl)-1H-5-nitrobenzimidazole
and 2-phenyl-1H-benzimidazole. None of the tetrazoles exhibited the antimicrobial
activities at the examined concentrations.
Conclusion:
These results suggest that the derivatives should be investigated further for possible use in antimicrobial
products.

Abstract Number: 80

Conference Year: 2014

Link to conference website: http://www.AAA2014.org

New link: NULL

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