Species Distribution and Susceptibility Profile of Yeasts Isolated from Blood Cultures: Preliminary Results of a Multicenter Study for Latin America

Ref ID: 18798

Author:

S. Córdoba, PhD – R1, M. Melhem, PhD – R 2, M. Dolande, MS – R 3, A. Puimé, PhD – R 4, G. Martí­nez, PhD – R 5, S. Zurita, PhD – R 6, M. Cuenca-Estrella, PhD – R 7, J. Rodrí­guez-Tudela, PhD – R 7, J. Gabastou, PhD – R 8, RLN;

Author address:

1INEI, Bs As, Argentina, 2IAL, SP, Brazil, 3INHRR, Caracas, Venezuela, Bolivarian Republic of, 4DLSP, Montevideo, Uruguay, 5IPK, LH, Cuba, 6INS, Lima, Peru, 7ISC III, Majadahonda, Spain, 8PAHO, SJO, Trinidad and Tobago.

Full conference title:

52nd Annual ICAAC

Date: 9 September 2014

Abstract:

Background: The epidemiology of yeast species causing fungemia varies in relation to the demographic and geographic origin. The Regional Laboratory Network for Surveillance of Invasive Fungal Infections and Antifungal Susceptibility in Latin America conducted a Multicenter survey on fungemia due to yeasts in Latin American countries. Preliminary results are presented. Methods: We conducted a prospective laboratory-based survey in 39 hospitals of 6 Latin American countries from June 2010 to April 2012. MIC and breakpoints were determined according to E.Def 7.2 (EUCAST) document. Species were identified following phenotypic and molecular techniques. Results: There were 521 episodes of fungemia due Candida spp. and related species. The most frequent species were Candida parapsilosis (39.9%), C. albicans (27.2%), C. tropicalis (18.2%) and C. guilliermondii (5.3%). Among infrequent species C. metapsilosis (0.3%), C. catenulata, C. lipolytica, C. orthopsilosis, C. zeylanoides, Kodamaea ohmeri and Pichia rhodanensis (0.2% each) were identified. MIC50 and MIC90, in mg/L were: 0.25 and 0.5 for amphotericin B (AB); 1 and 4 for fluconazole (FZ); 0.03 and 0.25 for itraconazole (IZ); 0.03 and 0.12 for voriconazole (VZ); 0.06 and 4 for anidulafungin (AN); 0.25 and 2 for caspofungin (CA); 0.015 and 0.06 for posaconazole. Resistance to AB occurred in 1% of C. parapsilosis isolates. For FZ, IZ and VZ resistance was 9.2, 3.7 and 6.1% respectively. The species less susceptible was C. guilliermondii (47.8, 25 and 30.2%). MICs >0.06 and >1 mg/L for AN and CA were observed in 45.6% and 31.5% of C. parapsilosis respectively. Conclusions: C. parapsilosis candidemia was prevalent. C. guilliermondii occupied the 4th place and was the species least susceptible to azole drugs. Rates of resistance are low and vary according yeasts species. Continuous surveillance programs in Latin American hospitals are needed.

Abstract Number: M-327

Conference Poster: y

Conference Year: 2012

Link to conference website: NULL

New link: NULL

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