Shuttling of entire MAPK module from membrane to nuclear envelope links fungal development to secondary metabolism

Ref ID: 18497

Author:

Özlem Sarikaya Bayram, Özgür Bayram, Yasar Luqman Ahmed, Jun Ichi Maruyama, Oliver Valerius, Ralf Ficner,
Stefan Irniger, Gerhard Braus

Author address:

Georg August University

Full conference title:

11 th European Conference on Fungal Genetics

Abstract:

The sexual Fus3 MAP kinase module of yeast is highly conserved in eukaryotes and transmits external signals from
plasma membrane to nucleus. The module of the filamentous fungus Aspergillus nidulans consisting of the AnFus3
MAP kinase, the upstream kinases AnSte7 and AnSte11 together with AnSte50 adaptor lacks the membrane
interacting Ste5 scaffold homolog of yeast. The entire MAPK module interact with each other at the plasma
membrane as in yeast. We find a different molecular mechanism how the MAPK signal is transmitted in the
filamentous fungus: not only Fus3 but the entire complex of four physically interacting proteins migrates from
plasma membrane to nuclear envelope. AnFus3 is the only subunit with the potential to enter the nucleus from
the nuclear envelope. AnFus3 phosphorylates the conserved nuclear transcription factor AnSte12 to initiate sexual
development and the conserved fungal velvet domain protein VeA to coordinate development with secondary
metabolite production. Our data define the nuclear envelope as an additional critical control point for signal
delivery of a MAP kinase pathway from the cellular surface through the cytoplasm to target regulators located
within the nucleus  

Abstract Number: PR.7.7

Conference Year: 2012

Link to conference website: http://www.ecfg.info/images/Abstract_Book_Electronic.pdf

New link: NULL

Conference abstracts, posters & presentations

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