Screening for New Antifungal Agents

Ref ID: 18729

Author:

Derek Law, PhD – Head of Microbiology

Author address:

F2G Ltd., Manchester, United Kingdom.

Full conference title:

52nd Annual ICAAC

Date: 9 September 2014

Abstract:

Novel antifungal agents are required to expand the antifungal armamentarium. Because of long development timelines we must be screening and searching now for drugs to be used in the clinic in 10 years time. Conventional microbiological screening still has a place in drug discovery but compound library selection is essential to provide novelty and diversity in the hits and compounds developed. The use of genomics to identify novel fungal targets led to various target based screening strategies which have largely been unsuccessful. Fragment based screening using carefully selected novel fungal targets may be a more successful approach as fragment hits are more amenable to development into drugs. In silico modelling and docking studies can be used alone or with existing techniques to assist and refine drug design and enable scaffold hopping. Using a combination of old and new techniques provides excellent opportunities for developing novel antifungals for the future.

Abstract Number: 1869

Conference Year: 2012

Link to conference website: NULL

New link: NULL

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