Revised and Expanded Estimate of Burden of Serious Fungal Infections in Argentina

D Denning1, F Riera2, JCaeiro2

Author address: 

1National Aspergillosis Centre, LIFE program, Manchester, U K 2Infectious Diseases, Universidad Nacional de Córdoba, Córdoba, Argentina

Abstract: 

Purpose: A preliminary estimate of the burden of serious fungal infections was presented in 2014, and has been expanded here, based on additional data. There is no national data or surveillance. 

Methods: Specific population statistics were sourced from multiple sources, local literature was identified and estimates made. Some additional data were sourced from the Ministry of Health, GINA program (asthma), and national haematology and transplant societies. 

Results: Argentina has a population of 43.6 million, with 25% children under 15 yrs. Estimated numbers and rates of key infections per year are in the Table. Predicted candidemia incidence is low at 2/100,000, with 82% occurring in the ICU. At a 6% prevalence rate, an estimated 593,695 women suffer from recurrent VVC. IA is relatively common because of a high smoking and COPD rate, 332 cases in immunocompromised patients and another 1,898 in the 146,000 COPD patients admitted to hospital. Asthma is common affecting14% of adults and so ABPA and SAFS are major problems. In AIDS an estimated 328 and 1,085 cases of cryptococcal meningitis (CM) and Pneumocystis pneumonia (PCP) occur. Histoplasmosis cases in AIDS are almost the same as CM. paracoccidioidomycosis is a relatively frequent. Fungal keratitis and tinea capitis frequency are also relatively frequent.

Conclusion: At least 882,000 people (>2.0%) in Argentina are affected by a serious fungal disease annually, with considerable morbidity and mortality. Probably invasive candidiasis, PCP, invasive aspergillosis and disseminated histoplasmosis are significantly under-diagnosed

2018

Full conference title: 

The 8th Advances Against Aspergillus, Lisbon Conference Center, Lisbon, Portugal
    • AAA 8th (2018)