Respiratory virus infections other than in64258; uenza virus in allogeneic stem cell transplant recipients

Ref ID: 18615

Author:

M. Tsuji (1), H. Araoka (1), A. Wake (2), A. Nishida (1), H. Ohta (1),
H. Shimazu (1), K. Ishiwata (1), N. Nakano (1), H. Yamamoto (1),
Y. Asano-Mori (1), K. Izutsu (1), N. Uchida (1), A. Yoneyama (1),
H. Nishimura (3), M. Saijo (4), S. Taniguc

Author address:

(1)Toranomon Hospital (Tokyo, JP); (2)Toranomon Hospital
Kajigaya (Kanagawa, JP); (3)Sendai Medical Center (Miyagi,
JP); (4)National Institute of Infectious Diseases (Tokyo, JP)

Full conference title:

Annual Meeting of the EBMT, 37th

Abstract:

Background: Respiratory virus infections following allogeneic
stem cell transplantation (alloSCT) have been sometimes associated with mortality and morbidity. We retrospectively analyzed
clinical features of respiratory virus infections of alloSCT recipients in our institute.
Methods: Oropharyngeal swab, sputum, or bronchoalveolar lavage fl uid were sampled from alloSCT recipients with respiratory
symptoms. Respiratory viruses were detected by viral culture or
RT-PCR. Respiratory virus infection was diagnosed by both the
presence of respiratory symptoms and detection of respiratory
virus. Upper (URTI) and lower respiratory tract infection (LRTI)
were diagnosed by radiologic fi ndings.
Results: We analyzed 530 recipients undergone alloSCT in
our institute from January 2006 to December 2010. Sixty-one
patients were diagnosed as respiratory virus infection. The
viruses detected included respiratory syncytial virus (RSV, 22
cases), parainfl uenza virus type 3 (PIV3, 37 cases), and adenovirus (ADV, 4 cases). In one patient, RSV and PIV3 were
detected in separated periods. LRTI by RSV, PIV3, and ADV
developed in 13 (59%), 10 (27%), 3 (75%) cases, and their
mortality rates were 61%, 50%, 66.7%, respectively. The coinfection of other pathogens (Pseudomonas aeruginosa, Stenotrophomonas maltophilia, Aspergillus spp., et al) was more
highly associated with the mortality of RSV LRTI than those of
PIV3 or ADV LRTIs. Risk factors for death by respiratory virus
infection were low lymphocyte counts (Lymphocyte <200/151;L), LRTI, and onset before neutrophil engraftment. And, although patients with respiratory virus infection were isolated immediately after the symptom developed, RSV and PIV3 caused outbreak in our transplant unit. Conclusion: Respiratory virus infections at early post-transplant period were associated with high mortality rate. Respiratory viruses also caused outbreak in transplant unit. Considering that effective treatments for these viruses have not been established, more rigorous preventative strategy, especially for those in high-risk group, is extremely important.

Abstract Number: P766

Conference Year: 2011

Link to conference website: NULL

New link: NULL

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