Pulmonary mucormycosis

Ref ID: 18627

Author:

A. Ferrao, M.J. Palare, M.E. Oliveira, J. Alves Carmo,
A. Morais

Author address:

CHLN (Lisbon, PT)

Full conference title:

Annual Meeting of the EBMT, 37th

Abstract:

Introduction: Mucormycosis, also known as zygomycosis, is a
rare opportunistic fungal infection that mostly affect immunocompromised patients. main clinical presentation is pulmonary
infection that is often indistinguishable from pulmonary Aspergillosis but doesn’t respond to tretment with voriconazole.
Case report: The authors report the case of a 12 years old boy
who underwent bone marrow transplantation for aplastic anemia, that since 6th day post transplantation showed an x-ray
opacity in the upper lobe of the left lung. Despite broad spectrum antibiotics combined with an antifungal agent (liposomal
amphotericin B) there wasn’t improvement. Chest computed
tomography showed a cavitated nodule contacting the left
apicl pleural suggesting fungal infection, probably aspergillosis.
Voriconazole was started but the radiological image persisted
and a month later was performed a left upper lobectomy. Histopathological examination of surgical specimen revealed a
mucormycosis. After surgery this boy was treated with liposomal
amphotericin B replaced 6 weeks later by oral posaconazol,with
good clinical and radiological response.
Discussion: This case illustrates the difi culties of differential
diagnosis between pulmonary aspergillosis and mucormycosis.
The fi rst choice antifungal therapy is amphotericin B. Posaconazole has been used in some cases that didn’t respond to amphotericin B. In most patients surgical debridement of necrotic
tissues that not allow antifungal agent penetration is essential.
In patients receiving immunossupressor agents secondary
prophylaxis shoul be discussed.

Abstract Number: P819

Conference Year: 2011

Link to conference website: NULL

New link: NULL

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