Production of terpenes with Aspergillus nidulans

Ref ID: 18384

Author:

Kiira Vuoristo, Kirsi Bromann, Mervi Toivari, Laura Ruohonen, Tiina Nakari-Setälä

Author address:

VTT
Technical Research Centre of Finland Address: Tietotie 2, Espoo, P.O. Box 1000, FI-02044 VTT, Finland. Email: kiira.vuoristo@vtt.fi

Full conference title:

Asperfest 8

Abstract:

Terpenes are a large and diverse group of hydrocarbons with many pharmaceutical and industrial applications including fragrances, preservatives,
flavouring agents and drugs. Terpenes with rearrangements in their carbon skeleton are referred to as terpenoids. The low water solubility, high volatility
and complex structure of terpenoids make them difficult to produce in industrial scale. Modification of readily available precursors of terpenoids in
filamentous fungi would present an alternative way to produce value-added compounds. There are not many reports on microbial transformation of
terpenoids by fungi of the Aspergillus genus, although their ability to transform terpenes is recognised. The biotransformation of terpenes is of interest
because it allows production of enantiomerically pure compounds under mild conditions. In nature, filamentous fungi produce terpenoids as secondary
metabolites; i.e. they are not required for growth or development but instead function in communication or defence. The fungal terpenoids are involved
in pathogenesis, production of toxins and utilization of specific carbon sources. Filamentous fungi have been used in industrial scale production and
especially Aspergillus niger and Aspergillus nidulans represent potential host organisms for the production and modification of terpenoid products. This
work describes genetic engineering of A. nidulans for terpenoid production.

Abstract Number: 62)

Conference Year: 2011

Link to conference website: NULL

New link: NULL

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