Population-Based Program of Aspergillus spp. Antifungal Resistance in Spain (FILPOP STUDY)

Ref ID: 18673

Author:

A. Alastruey-Izquierdo, PhD – Dr 1, E. Mellado, PhD – Dr 1, T. Pelaez, PhD – Dr 2, J. Peman, PhD – Dr 3, S. Zapico, PhD – Dr 4, M. Alvarez, PhD – Dr 5, M. Cuenca-Estrella, PhD, MD – Dr1, FILPOP Study Group;

Author address:

1Centro Nacional de Microbiologia. ISCIII, Majadahonda. Madrid, Spain, 2Hosp. Gregorio Marañón, Madrid, Spain, 3Hosp. La Fe, Valencia, Spain, 4Hosp. de Donostia, Guipuzcoa, Spain, 5Hosp. Central de Asturias, Oviedo, Spain.

Full conference title:

52nd Annual ICAAC

Date: 9 September 2014

Abstract:

Background: A population-based survey was conducted to investigate the frequency of antifungal resistance in clinical strains of Aspergillus spp. in Spain. Methods: The study was conducted in two different periods (October 2010 and May 2011) and included all patients admitted in 27 Spanish hospitals with a positive culture of filamentous fungus from respiratory samples, paranasal sinus aspirates, blood cultures and biopsies. They were identified by classical and molecular methods. Prevalence of sibling/cryptic species was also accounted. Susceptibility testing and interpretation were performed by EUCAST methodology and breakpoints. Results: Average prevalence was 0.02/1,000 admissions. 277 Aspergillus strains were isolated. 56% of the strains were identified as A. fumigatus sensu stricto, 9% as A. flavus, 9% as A. terreus, 8% as A. tubingensis, 7.5% as A. niger, 3% as A. nidulans, and 7.5% as other species. 22 (8%) were classified as resistant to AMB, 10 (3.6 %) to ICZ, 5 (2 %) to VCZ and 8 (3 %) to PCZ. All isolates of A. fumigatus were susceptible to all drugs except for one isolate that was resistant to PCZ. Resistance to AMB was observed in isolates of A. alliaceus, A.fumigatiaffinis, A. insuetus and A. westerdijikiae, 66% of A. lentulus strains, 22 % of A. flavus and 27% of A. terreus. Species of Aspergillus section Usti were resistant to all azoles tested. Itraconazole resistance was also found in all A. lentulus and A. fumigatiaffinis and one isolate of A. tubingensis. Conclusions: 1) Average prevalences of resistant isolates in the study were low (<8%) 2) Total rate of sibling/cryptic Aspergillus species was 15% and there were species-specific differences in antifungal susceptibility 3) Resistance was more frequent (>50%) in species belonging to those sibling/cryptic species.

Abstract Number: M-321

Conference Year: 2012

Link to conference website: NULL

New link: NULL

Conference abstracts, posters & presentations

Showing 10 posts of 17325 posts found.

  • Title

    Author

    Year

    Number

    Poster