Pneumonia After Solid Organ Transplantation: A Multicenter Prospective Study

Ref ID: 18805

Author:

M. Giannella, MD – Clinical Researcher1, P. Munoz, MD, PhD – Professor 1, J. Martinez Alarcon, MD – Microbiologist 2, P. Grossi, MD – Professor 3, E. Bouza, MD, PhD – Professor 1, on behalf of the PISOT study group;

Author address:

1Hosp. Gregorio Maranon, Madrid, Spain, 2Hosp. de Ciudad Real, Ciudad Real, Spain, 3Univ. of Insubria, Varese, Italy.

Full conference title:

52nd Annual ICAAC

Date: 9 September 2014

Abstract:

Background: Information on the current incidence, predisposing conditions, use of microbiological resources, etiology and outcome of pneumonia among patients with solid organ transplantation (SOT) is scarce. Methods: Italian and Spanish transplant centers were invited to report on all SOT patients with pneumonia occurring during 1 week in February 2012. The total amount of SOT patients under follow-up during the study week was requested to calculate the incidence of pneumonia. Results: 34 centers agreed to participate collecting 37 cases of pneumonia. Incidence of pneumonia during the study week resulted of 1.2 cases per 1,000 SOT patients followed. The cohort included: kidney (57%); heart (17%); liver (11%); lung (11%); lung-liver (3%) and kidney-pancreas (3%) recipients. The median age, Charlson score and Barthel index were 63 years (IQR 53-68), 5 (IQR 3-7) and 100 (IQR 85-100), respectively. Rates of chronic allograft dysfunction, retransplant in the past year, and biopsy proven rejection in the previous 3 months were 30, 8 and 3%, respectively. The onset of pneumonia after transplantation was late (>6 months) in 70% of patients. An attempt to microbiological diagnosis (≥ 1 sample) was made in all patients but one, with a diagnostic yield of 71.4%. Causative agents included: bacteria (76%), virus (40%), fungi (8%), and mixed infections (24%). P. aeruginosa, S. pneumoniae and Influenza virus were the most common pathogens. Reduction of immunosuppression therapy and use of immunoglobulins were done in 43 and 9% of patients, respectively. No case of in-hospital death was observed, 11% of patients required ICU admission and 26% experienced worsening of graft function. Univariate analysis showed that higher median PORT and CURB-65 scores were significantly (p8804;0.05) associated to ICU admission, while pneumonia caused by Aspergillus spp. and reduction of immunosuppression were associated to worsening of graft function. Conclusions: Preliminary data of our ongoing study showed a low incidence of pneumonia in SOT patients. Worsening of graft function was the most common complication.

Abstract Number: T-1041

Conference Year: 2012

Link to conference website: NULL

New link: NULL

Conference abstracts, posters & presentations

Showing 10 posts of 17325 posts found.

  • Title

    Author

    Year

    Number

    Poster