Other antiandrogens

Ref ID: 1912

Author: Schmidt, J. B.

Author address:

Schmidt, JB, Univ Vienna, Sch Med, Dept Dermatol, Waehringer Guertel 18-20, A-1090 Vienna, Austria

Full conference title:

4th International Dermatology Symposium on Sebaceous Gland, Acne and Related Disorders

Date: 7 May 2014


Various substances of steroidal or nonsteroidal structure may serve as an alternative for the antiandrogenic treatment of acne. Compounds with antiandrogenic properties like cimetidine or ketoconatole are rarely administered for acne due to their weak effects. In contrast, spironolactone is an effective antiandrogen that shows good treatment effects in hirsutism and acne. Side effects occur frequently and are dose dependent. Isotretinoin – the most effective agent in acne therapy – has been under discussion for additional antiandrogenic properties for years. At present there is additional evidence for the antiandrogenic effects of isotretinoin. Regarding substances acting on both levels, androgen receptor binding and 5 alpha- reductase inhibition, the question is raised whether the term ‘antiandrogen’ should be amplified by including the 5 alpha- reductase inhibitors. This would pay tribute to the biological aspect of antiandrogenicity that takes into account not only the mode of action but also the effects of the substance. Under this aspect type 1 5 alpha-reductase inhibitors may gain attention in the future.

Abstract Number: NULL

Conference Year: 1997

New link: NULL

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