Ocular infections caused by Candida species: type of species, in vitro susceptibility and treatment outcome

Ref ID: 19623

Author:

1Swapna R Motukupallv*.1Vidva R Nanapur/Somasheila Murthy,3Rajeev Reddy Pappuru,
4Aparajita Mallick,1,4Savitri Sharma

Author address:

‘Jhaveri Microbiology Centre, L.V. Prasad Eye Institute, Hyderabad, AP-500 034.2Cornea and Anterior Segment Service,
L.V Prasad Eye Institute, Hyderabad, AP-500 034.3Kanuri Santhamma Retina-Vitreous Service, L.V. Prasad Eye Institute,
Hyderabad, AP

Full conference title:

Society for Indian Human and Animal Mycologists 2014

Date: 10 January 2014

Abstract:

The study was conducted with a purpose to report clinical and microbiological profile of patients with ocular candidiasis
Microbiological experimental data combined with retrospective clinical study. Patients with ocular candidiasis were identified
from microbiology records. Significant isolates of Candida species were identified by Vitek 2 compact system. Using CLSI
guidelines minimum inhibitory concentration (MIC) of antifungal agents such as amphotericin B, itraconazole, voriconazole,
fluconazole and caspofungin was determined by E test and of natamycin by microbroth dilution assay. Data on treatment and
outcome were collected from medical records. A total of 36 isolates of Candida were obtained from patients with keratitis
(n=26), endophthalmitis (n=9) and orbital cellulitis («=1). The most common species isolated was Candida albicans (n=10)
from keratitis, (w=3) endophthalmitis, (n=l) orbital cellulitis. All isolates were susceptible to amphotericin B. MIC of
caspofungin was in the susceptible range of 25 (96.1%) comeal isolates while 11 out of 26 (42.3%) comeal isolates were
sensitive to fluconazole. Resistance to voriconazole was seen in two comeal isolates. None of the isolates were susceptible to
itraconazole and all keratitis isolates were susceptible to natamycin. Of the 11 keratitis patients who responded to medical
therapy, eight were treated with natamycin alone. All 9 isolates from endophthalmitis patients were susceptible to amphotericin
B, voriconazole and natamycin. Six out of eight patients with endophthalmitis were given intra vitreal amphotericin B injection
with variable outcome. Ocular candidiasis needs early and specific treatment for optimal results. Candida spp. continue to be
susceptible to most commonly available antifungals including amphotericin B, voriconazole and natamycin.
’Corresponding author
E-mail: swapnareddy@gmail.com

Abstract Number: OP-004

Conference Year: 2014

Link to conference website: http://www.siham2014.com

New link: NULL

Conference abstracts, posters & presentations

Showing 10 posts of 17325 posts found.

  • Title

    Author

    Year

    Number

    Poster