Nitric oxide (NO) is a morphogenetic signal in fungi

Ref ID: 18336

Author:

Ana T. Marcos*, Thorsten Schinko#, Joseph Strauss#, David Cánovas

Author address:

Departamento de
Genética, Facultad de Biologí­a, Universidad de Sevilla, Spain, davidc@us.es; #Fungal Genetics and Genomics Unit, AIT-Austrian Institute of Technology
and BOKU University, Vienna, Austria, joseph.strauss@boku.ac.at

Full conference title:

Asperfest 8

Abstract:

Nitric oxide (NO!) is an important signalling and defence molecule in higher eukaryotes, including plants and mammals. We recently showed that in
A. nidulans this short-lived nitrogen oxide radical is generated during the nitrate assimilation process, and that detoxification by flavohemoglobin proteins
FhbA and FhbB, which are co-regulated with the nitrate pathway, is required to protect nitrate- and nitrite reductase from nitrosative inactivation under
elevated NO! conditions (1). We here report the effect of nitric oxide donors and of mutations in fhbA and fhbB on developmental processes in two fungal
genera. In response to external and internal signals, all fungi undergo developmental programs to form specialized structures and in A. nidulans, there
is a fine balance between asexual (conidiation) and sexual development. We have found that addition of the NO!-releasing compound DetaNONOate
reduced asexual development in A. nidulans. On the other hand, the formation of sexual structures is increased after DetaNONOate supplementation in
several fungal species, including species from Aspergillus and Neurospora. (1) Schinko et al. (2010). Transcriptome analysis of nitrate assimilation in
Aspergillus nidulans reveals connections to nitric oxide metabolism. Mol. Microbiol. 78: 720-738.

Abstract Number: 14)

Conference Year: 2011

Link to conference website: NULL

New link: NULL

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